diff --git a/core/combo/include/arch/darwin-x86/AndroidConfig.h b/core/combo/include/arch/darwin-x86/AndroidConfig.h
index d3df919eeb..a64c1c0445 100644
--- a/core/combo/include/arch/darwin-x86/AndroidConfig.h
+++ b/core/combo/include/arch/darwin-x86/AndroidConfig.h
@@ -47,14 +47,6 @@
  */
 #define HAVE_SYMLINKS
 
-/*
- * We need to choose between 32-bit and 64-bit off_t.  All of our code should
- * agree on the same size.  For desktop systems, use 64-bit values,
- * because some of our libraries (e.g. wxWidgets) expect to be built that way.
- */
-#define _FILE_OFFSET_BITS 64
-#define _LARGEFILE_SOURCE 1
-
 /*
  * Add any extra platform-specific defines here.
  */