diff --git a/cc/compiler.go b/cc/compiler.go
index d13cd9506..83080fd72 100644
--- a/cc/compiler.go
+++ b/cc/compiler.go
@@ -695,6 +695,7 @@ func (compiler *baseCompiler) compilerFlags(ctx ModuleContext, flags Flags, deps
 
 	if ctx.optimizeForSize() {
 		flags.Local.CFlags = append(flags.Local.CFlags, "-Oz")
+		flags.Local.LdFlags = append(flags.Local.LdFlags, "-Wl,-mllvm,-enable-ml-inliner=release")
 	}
 
 	// Exclude directories from manual binder interface allowed list.
diff --git a/cc/lto.go b/cc/lto.go
index a084db7be..60eb4d6b1 100644
--- a/cc/lto.go
+++ b/cc/lto.go
@@ -144,7 +144,7 @@ func (lto *lto) flags(ctx ModuleContext, flags Flags) Flags {
 
 		if !ctx.Config().IsEnvFalse("THINLTO_USE_MLGO") {
 			// Register allocation MLGO flags for ARM64.
-			if ctx.Arch().ArchType == android.Arm64 {
+			if ctx.Arch().ArchType == android.Arm64 && !ctx.optimizeForSize() {
 				ltoLdFlags = append(ltoLdFlags, "-Wl,-mllvm,-regalloc-enable-advisor=release")
 			}
 			// Flags for training MLGO model.