diff --git a/cc/config/arm64_linux_host.go b/cc/config/arm64_linux_host.go
index 9f5124bb4..335ad5672 100644
--- a/cc/config/arm64_linux_host.go
+++ b/cc/config/arm64_linux_host.go
@@ -46,6 +46,10 @@ var (
 		"-Wl,--no-undefined-version",
 	}
 
+	linuxCrossLldflags = append(linuxCrossLdflags,
+		"-Wl,--compress-debug-sections=zstd",
+	)
+
 	// Embed the linker into host bionic binaries. This is needed to support host bionic,
 	// as the linux kernel requires that the ELF interpreter referenced by PT_INTERP be
 	// either an absolute path, or relative from CWD. To work around this, we extract
@@ -60,6 +64,7 @@ var (
 func init() {
 	exportedVars.ExportStringListStaticVariable("LinuxBionicArm64Cflags", linuxCrossCflags)
 	exportedVars.ExportStringListStaticVariable("LinuxBionicArm64Ldflags", linuxCrossLdflags)
+	exportedVars.ExportStringListStaticVariable("LinuxBionicArm64Lldflags", linuxCrossLldflags)
 }
 
 // toolchain config for ARM64 Linux CrossHost. Almost everything is the same as the ARM64 Android
diff --git a/cc/config/arm_linux_host.go b/cc/config/arm_linux_host.go
index 525fb5d5d..e21c60d63 100644
--- a/cc/config/arm_linux_host.go
+++ b/cc/config/arm_linux_host.go
@@ -27,16 +27,24 @@ var (
 		"-march=armv7a",
 	}
 
+	linuxArmLldflags = append(linuxArmLdflags,
+		"-Wl,--compress-debug-sections=zstd",
+	)
+
 	linuxArm64Ldflags = []string{}
+
+	linuxArm64Lldflags = append(linuxArm64Ldflags,
+		"-Wl,--compress-debug-sections=zstd",
+	)
 )
 
 func init() {
 	exportedVars.ExportStringListStaticVariable("LinuxArmCflags", linuxArmCflags)
 	exportedVars.ExportStringListStaticVariable("LinuxArm64Cflags", linuxArm64Cflags)
 	exportedVars.ExportStringListStaticVariable("LinuxArmLdflags", linuxArmLdflags)
-	exportedVars.ExportStringListStaticVariable("LinuxArmLldflags", linuxArmLdflags)
+	exportedVars.ExportStringListStaticVariable("LinuxArmLldflags", linuxArmLldflags)
 	exportedVars.ExportStringListStaticVariable("LinuxArm64Ldflags", linuxArm64Ldflags)
-	exportedVars.ExportStringListStaticVariable("LinuxArm64Lldflags", linuxArm64Ldflags)
+	exportedVars.ExportStringListStaticVariable("LinuxArm64Lldflags", linuxArm64Lldflags)
 
 	exportedVars.ExportStringListStaticVariable("LinuxArmYasmFlags", []string{"-f elf32 -m arm"})
 	exportedVars.ExportStringListStaticVariable("LinuxArm64YasmFlags", []string{"-f elf64 -m aarch64"})
diff --git a/cc/config/global.go b/cc/config/global.go
index 62b008b06..666893778 100644
--- a/cc/config/global.go
+++ b/cc/config/global.go
@@ -133,6 +133,9 @@ var (
 		// Using simple template names reduces the size of debug builds.
 		"-gsimple-template-names",
 
+		// Use zstd to compress debug data.
+		"-gz=zstd",
+
 		// Make paths in deps files relative.
 		"-no-canonical-prefixes",
 	}
@@ -200,7 +203,9 @@ var (
 		"-Wl,-mllvm,-regalloc-enable-advisor=release",
 	}
 
-	deviceGlobalLldflags = append(deviceGlobalLdflags, commonGlobalLldflags...)
+	deviceGlobalLldflags = append(append(deviceGlobalLdflags, commonGlobalLldflags...),
+		"-Wl,--compress-debug-sections=zstd",
+	)
 
 	hostGlobalCflags = []string{}
 
diff --git a/cc/config/x86_linux_bionic_host.go b/cc/config/x86_linux_bionic_host.go
index e0064717d..f80be9915 100644
--- a/cc/config/x86_linux_bionic_host.go
+++ b/cc/config/x86_linux_bionic_host.go
@@ -53,6 +53,10 @@ var (
 		"--gcc-toolchain=${LinuxBionicGccRoot}",
 	}
 
+	linuxBionicLldflags = append(linuxBionicLdflags,
+		"-Wl,--compress-debug-sections=zstd",
+	)
+
 	// Embed the linker into host bionic binaries. This is needed to support host bionic,
 	// as the linux kernel requires that the ELF interpreter referenced by PT_INTERP be
 	// either an absolute path, or relative from CWD. To work around this, we extract
@@ -71,7 +75,7 @@ const (
 func init() {
 	exportedVars.ExportStringListStaticVariable("LinuxBionicCflags", linuxBionicCflags)
 	exportedVars.ExportStringListStaticVariable("LinuxBionicLdflags", linuxBionicLdflags)
-	exportedVars.ExportStringListStaticVariable("LinuxBionicLldflags", linuxBionicLdflags)
+	exportedVars.ExportStringListStaticVariable("LinuxBionicLldflags", linuxBionicLldflags)
 
 	// Use the device gcc toolchain for now
 	exportedVars.ExportStringStaticVariable("LinuxBionicGccVersion", x86_64GccVersion)
diff --git a/cc/config/x86_linux_host.go b/cc/config/x86_linux_host.go
index 93aa82ec5..f95da0b3b 100644
--- a/cc/config/x86_linux_host.go
+++ b/cc/config/x86_linux_host.go
@@ -59,6 +59,10 @@ var (
 		"--gcc-toolchain=${LinuxGccRoot}",
 	}
 
+	linuxLldflags = append(linuxLdflags,
+		"-Wl,--compress-debug-sections=zstd",
+	)
+
 	linuxGlibcLdflags = []string{
 		"--sysroot ${LinuxGccRoot}/sysroot",
 	}
@@ -138,7 +142,7 @@ func init() {
 
 	exportedVars.ExportStringListStaticVariable("LinuxCflags", linuxCflags)
 	exportedVars.ExportStringListStaticVariable("LinuxLdflags", linuxLdflags)
-	exportedVars.ExportStringListStaticVariable("LinuxLldflags", linuxLdflags)
+	exportedVars.ExportStringListStaticVariable("LinuxLldflags", linuxLldflags)
 	exportedVars.ExportStringListStaticVariable("LinuxGlibcCflags", linuxGlibcCflags)
 	exportedVars.ExportStringListStaticVariable("LinuxGlibcLdflags", linuxGlibcLdflags)
 	exportedVars.ExportStringListStaticVariable("LinuxGlibcLldflags", linuxGlibcLdflags)
diff --git a/rust/config/global.go b/rust/config/global.go
index b94d92fd9..4d31121e5 100644
--- a/rust/config/global.go
+++ b/rust/config/global.go
@@ -65,6 +65,7 @@ var (
 		"-lpthread",
 		"-lm",
 		"-lgcc_s",
+		"-Wl,--compress-debug-sections=zstd",
 	}
 
 	deviceGlobalRustFlags = []string{
@@ -86,6 +87,7 @@ var (
 		"-Wl,--use-android-relr-tags",
 		"-Wl,--no-undefined",
 		"-B${cc_config.ClangBin}",
+		"-Wl,--compress-debug-sections=zstd",
 	}
 )
 
diff --git a/scripts/strip.sh b/scripts/strip.sh
index d09c187b1..7b360bf5f 100755
--- a/scripts/strip.sh
+++ b/scripts/strip.sh
@@ -98,9 +98,17 @@ do_strip_keep_mini_debug_info_linux() {
     "${CLANG_BIN}/llvm-strip" --strip-all --keep-section=.ARM.attributes --remove-section=.comment "${infile}" -o "${outfile}.tmp" || fail=true
 
     if [ -z $fail ]; then
-        "${CREATE_MINIDEBUGINFO}" "${infile}" "${outfile}.mini_debuginfo.xz"
+        # create_minidebuginfo has issues with compressed debug sections. Just
+        # decompress them for now using objcopy which understands compressed
+        # debug sections.
+	# b/306150780 tracks supporting this directly in create_minidebuginfo
+        decompressed="${infile}.decompressed"
+        "${CLANG_BIN}/llvm-objcopy" --decompress-debug-sections \
+                "${infile}" "${decompressed}"
+
+        "${CREATE_MINIDEBUGINFO}" "${decompressed}" "${outfile}.mini_debuginfo.xz"
         "${CLANG_BIN}/llvm-objcopy" --add-section .gnu_debugdata="${outfile}.mini_debuginfo.xz" "${outfile}.tmp"
-        rm -f "${outfile}.mini_debuginfo.xz"
+        rm -f "${outfile}.mini_debuginfo.xz" "${decompressed}"
     else
         cp -f "${infile}" "${outfile}.tmp"
     fi