diff --git a/README.md b/README.md
index 529b7e46..c272ce89 100644
--- a/README.md
+++ b/README.md
@@ -62,6 +62,9 @@ dnf install \
 # For Python and Ruby bindings
 dnf install \
     python3-devel \
+    python3-pip \
+    python3-setuptools \
+    python3-wheel \
     ruby-devel \
     swig
 ```
@@ -92,6 +95,9 @@ apt-get install --no-install-recommends --no-install-suggests \
 # For Python and Ruby bindings
 apt-get install --no-install-recommends --no-install-suggests \
     python3-dev \
+    python3-pip \
+    python3-setuptools \
+    python3-wheel \
     ruby-dev \
     swig
 ```
@@ -102,7 +108,7 @@ To build and install everything under a private directory, run:
 
     make DESTDIR=~/obj install install-rubywrap install-pywrap
 
-On Debian `PYTHON_SETUP_ARGS=--install-layout=deb` needs to be set when installing the python wrappers in order to create the correct python directory structure.
+On Debian `PYTHON_SETUP_ARGS='--install-option "--install-layout=deb"'` needs to be set when installing the python wrappers in order to create the correct python directory structure.
 
 To run tests with the built libraries and programs, several paths (relative to `$DESTDIR`) need to be added to variables `$LD_LIBRARY_PATH`, `$PATH` and `$PYTHONPATH`.
 This can be done using [./scripts/env_use_destdir](./scripts/env_use_destdir):
diff --git a/libselinux/src/Makefile b/libselinux/src/Makefile
index dc284832..0f6396ab 100644
--- a/libselinux/src/Makefile
+++ b/libselinux/src/Makefile
@@ -187,7 +187,7 @@ install: all
 	ln -sf --relative $(DESTDIR)$(SHLIBDIR)/$(LIBSO) $(DESTDIR)$(LIBDIR)/$(TARGET)
 
 install-pywrap: pywrap
-	$(PYTHON) setup.py install --prefix=$(PREFIX) `test -n "$(DESTDIR)" && echo --root $(DESTDIR)` $(PYTHON_SETUP_ARGS)
+	$(PYTHON) -m pip install --prefix=$(PREFIX) `test -n "$(DESTDIR)" && echo --root $(DESTDIR)` $(PYTHON_SETUP_ARGS) .
 	install -m 644 $(SWIGPYOUT) $(DESTDIR)$(PYTHONLIBDIR)/selinux/__init__.py
 	ln -sf --relative $(DESTDIR)$(PYTHONLIBDIR)/selinux/_selinux$(PYCEXT) $(DESTDIR)$(PYTHONLIBDIR)/_selinux$(PYCEXT)
 
diff --git a/python/sepolicy/Makefile b/python/sepolicy/Makefile
index d983e409..57a2e55e 100644
--- a/python/sepolicy/Makefile
+++ b/python/sepolicy/Makefile
@@ -27,7 +27,7 @@ test:
 	@$(PYTHON) test_sepolicy.py -v
 
 install:
-	$(PYTHON) setup.py install --prefix=$(PREFIX) `test -n "$(DESTDIR)" && echo --root $(DESTDIR)` $(PYTHON_SETUP_ARGS)
+	$(PYTHON) -m pip install --prefix=$(PREFIX) `test -n "$(DESTDIR)" && echo --root $(DESTDIR)` $(PYTHON_SETUP_ARGS) .
 	[ -d $(DESTDIR)$(BINDIR) ] || mkdir -p $(DESTDIR)$(BINDIR)
 	install -m 755 sepolicy.py $(DESTDIR)$(BINDIR)/sepolicy
 	(cd $(DESTDIR)$(BINDIR); ln -sf sepolicy sepolgen)